Fri Sep 26 2025

108 articles - From Friday Sep 19 2025 to Friday Sep 26 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastroenterology

AGA Clinical Practice Guideline on Management of Gastroparesis.

The diagnosis of gastroparesis requires the use of 4-hour gastric emptying tests. Metoclopramide or erythromycin is appropriate for initial pharmacologic treatment. Other treatment recommendations require shared patient-physician decision making. There are still considerable unmet needs in the treatment of gastroparesis.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Meta-Analysis: Mortality Trends and Risk Factors in Severe Alcohol-Associated Hepatitis.

Short-term mortality in sAH remains high and has not improved in recent decades. These findings highlight the urgent need for effective therapies, improved patient selection for early liver transplantation, and better prognostic tools to guide clinical decision-making.

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Systematic Review: Ultrasound Goes Echo-Decarbonising Inflammatory Bowel Disease Care Through Intestinal Ultrasound.

GI endoscopy, CT and MRI are indispensable in IBD care but carry considerable environmental costs. The broader adoption of IUS offers a clinically effective, low-carbon alternative that can contribute to more sustainable IBD management, aligning with planetary health goals.

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Clin Gastroenterol Hepatol

Performance of Fecal Immunochemical Test in Individuals with Personal history of Polyps and Family History of Colorectal Cancer: A Systematic Review.

Current evidence is limited to adequately assess diagnostic performance of FIT in individuals with family history of CRC, or as follow up after polypectomy.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Cost-Utility Analysis of Biomarker-Based vs. USG + AFP Strategies for HCC Surveillance in Chronic Hepatitis B.

ASAP every 6 months is the most cost-effective HCC surveillance strategy for patients with CHB and may be particularly suitable for resource-limited settings. Biomarker-based surveillance should be prioritised to improve outcomes and optimise resource use.

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Exploration of Multiple Non-Invasive Tests for Assessing Response to Treatment in a Semaglutide Phase 2b Trial in Patients With MASH.

NITs may be used for assessing a treatment response in patients with MASH. Further studies should confirm the treatment effect of NITs and evaluate the association of NIT changes to outcomes.

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Non-Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis.

Biochemical response stratifies risk of clinical events in PBC patients under OCA treatment. Whilst response rates increase over time, discontinuation rates underscore the need for newer treatment paradigms.

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Research Communication: Reflux Disease May Constitute a Risk Factor for Colonic Neoplasia.

CP and CRC were significantly associated with EE, NERD and BE. Our results suggest that reflux disease is associated with an increased risk for colonic neoplasia.

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Research Communication: The Cumulated Spontaneous Portosystemic Shunts (SPSS) Area Decreases After TIPS and Impacts on Prognosis.

Relative SPSS area decrease was an independent protective factor for mortality (asHR: 0.19; 95% CI: 0.04-0.88; p = 0.034). In conclusion, SPSS decrease after TIPS and relative SPSS area change is independently linked to survival, while total shunt area remains unaltered.

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Clin Gastroenterol Hepatol

Behavioral Interventions Improve Mailed Colorectal Cancer Screening Among Overdue Patients in a Randomized Trial.

Behaviorally-informed text messaging and mailed reminders significantly increased screening completion, but the health system branded box did not increase response rates.

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Differential Effects of Cardiometabolic Risk Factors on All-Cause Mortality in US Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

In age-adjusted analysis, number of CMRFs was associated with greater risk for mortality (aHR 1.15 per additional CMRF, 95%CI 1.10-1.20, p<0.001) CONCLUSIONS: The differential risk for mortality between individual CMRFs supports distinct clinical profiles in MASLD. This study found that high blood pressure and glucose intolerance exerted the greatest risk for all-cause mortality in those with MASLD, suggesting a role for prioritization of CMRF optimization.

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Long-term Results of Drug Treatment for Crohn's Disease Strictures.

The clinical response to adalimumab is durable in a majority of patients beyond four years of therapy. In patients with symptomatic Crohn's disease strictures, drug treatment is a viable initial treatment.

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Prevalence of fibrosis and applicability of lab-based non-invasive tests from primary to tertiary care.

Prevalence of fibrosis in contemporary SLD patients was ∼7% in primary/secondary care, being especially pronounced in individuals with diabetes or obesity. LiverPRO and LiverRisk score optimize referral pathways.

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Endosc Int Open

Amber-red color imaging makes the dissection line more evident during gastric endoscopic submucosal dissection.

ACI highlights the submucosa in blue only where sufficient solution is injected, which facilitates recognition of the dissection line during ESD.

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Differences in complications between colonoscopy and esophagogastroduodenoscopy in Japan using large-scale health insurance claims data.

Compared with EGD, CS had a higher rate of perforation but not hemorrhage. Complication rates in CS did not differ by age.

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Minimum standards for training in colorectal endoscopic mucosal resection among advanced endoscopy trainees.

The relatively low number of C-EMRs performed by many AETs may be insufficient to achieve competence. The estimated thresholds for an average AET to achieve competence in C-EMR provide a framework for AETPs in determining the minimal standards for case volume exposure during training.

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Narrow band imaging complements eosinophilic esophagitis reference score in predicting inflammatory infiltration in patients with dysphagia.

Positive NBI signs and furrows were the best predictors of eosinophile infiltration, whereas lymphocytic infiltration was predicted by edema. Given that NBI is already widely available, we encourage use of both white light and NBI in patients with suspected esophageal inflammation.

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Gastrointest Endosc

Endosonography guided Coloenterostomy for Palliative Management of Peritoneal Carcinomatosis.

EUS-guided CE for palliative management of SBI caused by peritoneal carcinomatosis is feasible and safe. The intervention boasts a high clinical success rate with immediate symptom relief and significant improvement of symptom-compensated and overall survival.

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Gut

Alleviated T cell exhaustion and SLC1A3-mediated stroma-remodelling dictate chemoimmunotherapy efficacy in oesophageal squamous cell carcinoma.

This study elucidates the synergistic mechanisms and identifies key resistance pathways underlying chemo-immunotherapy combinations in patients with ESCC, providing a scientific basis for refining future combination therapeutic regimens.

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Gastrin-dependent expansion of Cck2r<sup>+</sup> corpus progenitors accelerates ulcer healing and inhibits gastric dysplasia.

We report a novel role for G-cell-derived gastrin in ulcer healing. Hypogastrinaemia is a risk factor for poor ulcer healing, corpus atrophy and potentially cancer, while physiological gastrin responses are protective. PPI-induced hypergastrinaemia plays a key role in ulcer healing, and gastrin signalling may prevent gastric preneoplasia.

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Glycaemic control is a modifiable risk factor for pancreatic cancer development in patients with diabetes: a population-based cohort study.

Optimal glycaemic control was associated with lower PC risk in T2D. Further multicentre cohort studies are warranted to confirm its oncopreventive strategy.

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Hepatology

'Point-of-Care Ultrasound (POCUS) guided volume management and the effect of cirrhotic cardiomyopathy on acute kidney injury outcomes in cirrhosis'.

POCUS facilitates volume management and AKI reversal in cirrhosis. CCM predicts poor outcomes in HRS-AKI, need for RRT, and mortality.

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Bile acid signaling in MASLD: from pathogenesis to therapeutic applications.

Therapeutic strategies targeting these BA receptors along the gut-liver axis, either directly through agonists or indirectly via modulation of BA transport, are currently within the focus of clinical research. This review summarizes mechanistic aspects of BA signaling in MASLD, key evidence of experimental and clinical studies on BA receptor agonists and provides an outlook for future opportunities and challenges on the road to the implementation of novel therapies targeting BA receptors and BA signaling in MASLD.

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Evolving Precision: Updates in Targeted Therapy for Cholangiocarcinoma.

We will provide an overview of available single-gene analyses that should be considered in case of lack of access to NGS, defining testing priorities, differences in yields, and therapeutic implications. Lastly, we will discuss future perspectives in the field of precision medicine for BTC, focusing on new strategies to overcome treatment resistance, on the optimal collocation of targeted drugs in the treatment algorithm, and on newly identified actionable alterations for which compounds are currently under investigation.

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FXR splicing by SF3B3 promotes MYC-driven hepatocarcinogenesis.

SF3B3 is a key downstream effector of MYC-driven hepatocarcinogenesis and a critical regulator of FXR splicing. Both SF3B3 and FXR represent druggable vulnerabilities in MYC-amplified HCC.

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J Hepatol

Nivolumab plus ipilimumab for potentially resectable hepatocellular carcinoma: long-term efficacy and biomarker exploration.

Neoadjuvant nivolumab plus ipilimumab followed by surgery is feasible and might improve long-term survival in patients with potentially resectable HCC. Immunotherapy-induced TLS formation is associated with enhanced antitumor immunity. Clinical trial number NCT03510871.

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Strategies to address non-proportional hazards between survival curves - Lessons from phase III trials in hepatocellular carcinoma.

NPH caused discrepancies in IMbrave050's interim and subsequent efficacy analyses. Robust IA requires a minimum follow-up duration or number of events before prematurely stopping an RCT with NPH. Impact and implications Non-proportional hazards (NPH) impact phase III RCTs in hepatocellular carcinoma (HCC), particularly in immunotherapy trials, potentially causing discrepancies between the interim and final analyses. In fact, halting trials at the interim analysis can be premature when NPH is present. Thus, we propose a framework to ensure study maturity based on follow-up duration and event accruals to optimize interim analyses in the presence of NPH. Whenever NPH is identified, distinct statistical tools should be used to assess reliable differences between arms (MaxCombo) and to assess the effect size [restricted mean survival time (RMST) and piecewise hazard ratios (pHR)] for regulatory decisions and clinical guidance. Implementing these strategies can improve trial design, and better support decision-making for HCC management.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Gastrointest Endosc

A bit too heated: not all dysplastic Barrett's esophagus should be treated.

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A note from the Editor-in-Chief.

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A stitch in tine saves nine.

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Admit or discharge patients after gastric peroral endoscopic myotomy: Should I stay or should I go?

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Bouncing back: physical recovery after endoscopic submucosal dissection and transanal minimally invasive surgery.

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Endoscopic balloon dilation for inflammatory bowel disease strictures: Who benefits the most?

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Endoscopic septotomy for Zenker's diverticulum: Open for discussion?

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Pancreatic biopsy for indeterminate autoimmune pancreatitis: closer to eliminating misdiagnosis.

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Predicting incomplete endoscopic resection of ampullary adenomas: Are you keeping score?

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Gut

AI-empowered human microbiome research.

Additionally, we explore the transformative impact of AI on translational applications across both academic research and real-world clinical settings, including disease diagnostics, therapeutic development and precision microbiome engineering. By critically evaluating the current capabilities and limitations of AI in this context, this review aims to chart a path forward for the integration of AI into microbiome research, ultimately accelerating innovations in personalised medicine and deepening our understanding of host-microbiome relationships.

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Epigenetic therapies in hepatocellular carcinoma: emerging clinical tools and applications.

Importantly, we discuss how targeting epigenetic mechanisms may not only suppress tumour growth but also enhance the effectiveness of current therapies by reversing resistance pathways. By translating complex molecular insights into tangible therapeutic strategies, epigenetics is poised to reshape the future of HCC management, offering renewed hope for more durable and personalised treatment responses in a disease where progress is urgently needed.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Correction to: Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis: A Randomized Pilot Study.

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Finite Treatments for Viral Hepatitis: Is "Sustained Control" Versus Cure Acceptable for HBV?

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Mechanisms and Management of Ileus.

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Response to Borras-Blasco et al.

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Response to Karkra.

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Clin Gastroenterol Hepatol

Artificial Intelligence-Based Detection of Achalasia on Plain Chest Radiography.

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Metastatic Cystic Teratoma Presenting with Upper Gastrointestinal Bleeding.

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Endosc Int Open

Novel segmentally deployable self-expandable metallic stent in malignant colorectal obstruction.

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Endoscopy

A novel guidewire technique for endoscopic mucosal resection of ileocecal valve lesions.

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A rare extraction basket impaction: tracing back to biliary tract surgery 10 years ago.

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Balloon compression technique using an echoendoscopic balloon tip to prevent bile leakage in endoscopic ultrasound-guided choledochoduodenostomy.

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Delayed bleeding after peroral endoscopic myotomy for achalasia: conquered by clearing tunnel clots and identifying the bleeding site.

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Direct peroral cholangioscopic diagnosis and metal stent failure in a case of refractory arterial hemobilia.

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Endoscopic management of delayed post-papillectomy perforation.

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Endoscopic management of extensive ileocolic intussusception in Peutz-Jeghers syndrome is able to avoid surgery.

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Endoscopic retrieval of fragmented pancreatic stent in pediatric pancreas divisum using pancreatoscopy.

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Endoscopic submucosal dissection for early cancer using the water pressure method in the remnant rectum after Hartmann's procedure.

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Endoscopic subserosal dissection combined with the pocket-creation method for the treatment of exophytic gastric gastrointestinal stromal tumor.

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Endoscopic ultrasound-guided ablation of a metastatic hepatogastric lymph node from esophageal cancer using absolute ethanol.

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Endoscopic ultrasound-guided selective inflow vessel devascularization: a novel approach in treatment of large gastric varices.

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Endoscopy E-Videos - recently published.

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Esophageal metastasis from hepatocellular carcinoma after orthotopic liver transplantation.

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Management of T1 colon carcinoma: less is more.

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Non-thermal resection device for residual Barrett ablation in patient already treated by endoscopic submucosal dissection for initial esophageal neoplasia with high grade dysplasia.

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Rescue method using a covered metal stent with an ultra-slim delivery system for failed endoscopic ultrasound-guided rendezvous.

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Salvage hemostasis with endoscopic suturing for refractory transverse colonic ulcer bleeding.

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Same evidence but different recommendations - Dilemma in computer-aided detection in colonoscopy.

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Short-tunnel submucosal tunneling endoscopic resection for the removal of a rectal gastrointestinal stromal tumor above the dentate line.

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Submucosal saline injection-assisted endoscopic ultrasonography for accurate layer identification of a rectal subepithelial lesion.

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Toward precision selection in endoscopic intermuscular dissection for rectal cancer.

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Gastroenterology

A rare case of recurrent abdominal pain with facial edema.

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An Atypical Presentation of a Typical Pancreatic Cyst.

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Long-term outcomes of increased versus conventional adalimumab dose interval for patients with Crohn's disease in stable remission: 3-year follow-up of the randomized controlled LADI trial.

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Performance of Capsule Sponge Results Combined with Clinical Parameters in the Risk Stratification of Patients with Barrett's Esophagus.

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Gut

Dissecting the immune pathogenesis of HBV-ACLF through single-cell multimodal analysis.

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Hepatology

A targeted liver cancer therapy independent of immune checkpoint block.

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Letter to the Editor: Concerns regarding the diagnostic utility of non-invasive tests for clinically significant liver disease.

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Letter to the Editor: Key advance in noninvasive fibrosis assessment: Evidence from China.

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Letter to the Editor: Screening and risk stratification disparities in hispanic MASLD.

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REPLY: Concerns regarding the diagnostic utility of non-invasive tests for clinically significant liver disease.

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Reply: "Screening and risk stratification disparities in hispanic MASLD".

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Reply: Key advance in noninvasive fibrosis assessment: Evidence from China.

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Reply: Technical considerations in the development of a multimodal deep learning model for predicting hepatocellular carcinoma outcomes.

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Reply: a prognostic model in patients with alcohol-related cirrhosis does exist.

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J Hepatol

From the Editor's Desk...

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Letter: Drug-Induced Autoimmune-Like Hepatitis-A Trigger on the Disease Spectrum.

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Letter: Drug-Induced Autoimmune-Like Hepatitis-A Trigger on the Disease Spectrum. Authors' Reply.

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Clin Gastroenterol Hepatol

Advanced therapies in Crohn's disease: a critical appraisal of location-based efficacy.

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Response to "Fulminant Clostridioides difficile Infection Following Fecal Microbiota Spores Compared to Fecal Microbiota Transplant".

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This Letter to the Editor is in response to: Response to Fulminant Clostridioides difficile Infection Following Fecal Microbiota Spores Compared to Fecal Microbiota Transplant.

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Gastrointest Endosc

Coil placement for gastric varices: Do we have some additional TIPS?

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Comments on the Multicenter prospective study of a novel spiral-designed plastic stent in malignant hilar biliary obstruction: suggestions for evidence optimization.

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Efficiency in the endoscopy suite.

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How to safely implement and promote same-day discharge after gastric peroral endoscopic myotomy.

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Interpreting comparative effectiveness of endoscopic mucosal resection versus surgery: the challenge of selection bias.

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Radiation-free ERCP in pregnancy: an important consideration.

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Self-expandable metal stents and the risk of post-ERCP pancreatitis.

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Gut

Biliary sludge and microlithiasis: are we covering the full spectrum of lithogenic biliary disorders?

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Differentiating gastroparesis from functional dyspepsia is no longer sufficient.

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Lumen-apposing metal stents for pancreatic fluid collections: has advancing technology encouraged over-reach?

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Setting a vision for British Society of Gastroenterology guidelines: embracing innovation while preserving methodological excellence and clinical utility.

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J Hepatol

Advocating for scalable etiology-agnostic HCC risk models for personalized HCC surveillance.

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Beyond Relative Thresholds: Towards Actionable Interventions for Alcohol-Attributable Liver Mortality.

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Concerns on Rivaroxaban Use in Cirrhosis: Pharmacokinetic, Safety, and Bleeding Risk Considerations.

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Is it better to base care of patients on evidence even limited, or on opinions and good intentions?

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Oral Bis-choline Tetrathiomolybdate Rapidly Improves Copper Balance in Patients with Wilson Disease.

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Response to: "Addressing the Complexities of Food Insecurity and MASLD".

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Separating diet from drinking in alcohol-attributable liver mortality analyses.

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Too sick to benefit? Patient selection and timing in the ProPILA-Rifax trial.

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Unaddressed limitations in the CIRROXABAN trial: Safety, baseline imbalances, and statistical concerns.

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